Increased neuronal glutathione production from acetylcysteine can increase efflux of MeHg + from the brain via the glutathione + MeHg complex using the multidrug resistance protein and reduce brain MeHg + concentrations [Citation41, Citation42] ( in vitro neurons, astrocytes, neuroblastoma cells and myogenic cells incubated with MeHg + or Hg +2 and treated with acetylcysteine showed reduced oxidation injury, increased cell viability and blocked Hg-induced reduction of DNA synthesis [Citation36, Citation37, Citation43, Citation44]
Long-term antidepressant studies regarding weight gain show that weight fluctuations may persist for years during and following treatment [7, 8]
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